Testosterone was first discovered in the 19th century, when a French scientist named Browne-Sequard experimented with animal Testosterone on his own body and suggested many benefits.
By 1935, Testosterone had been produced synthetically as an anabolic steroid. In 1945 a widely read book called "The Male Hormone" resulted in experimentation and ultimately abuse amongst athletes and bodybuilders.
Consequently, the use of Testosterone as a therapy has been, until recently, discouraged. Research into Testosterone concentrated on the negatives of its abuse, rather than the positives of its careful use in therapy.
The 1990's produced much more research in the area of Testosterone deficiency and the subject as a whole is becoming slowly more understood. Better testing instructions are at hand and supplements are becoming much more effective and controllable.

Doctors have not been trained to identify Testosterone deficiency, with the result society must deal with an important health issue in the face of historical, and continuing, denial of its importance.

Replacing Testosterone is now known to be beneficial in the treatment of a large number of diseases and conditions. The AACE now suggest General Practitioners need to be more aware of the need to detect and treat Testosterone deficiency, as its importance to the health and well being of men and women is now becoming too clear to ignore any longer.