Testosterone Treatment Options
Treatment Options vary across the world, although this issue is slowly becoming resolved.
Existing global Testosterone treatments are as follows
Injections once a week or longer, dependent on dose and activity levels.
Pellet implants - a minor operation every three to four months.
Transdermal patches - Daily with potential adhesion problems during excercise.
Pills - Up to four a day. Not generally recommended by doctors.
Transdermal Gels (except Asia and Africa) - daily application with slight risk of transferrance.
In the Pipeline
A nasal spray has been licensed for production in the USA.
Tostrelle and Intrinsa for women are both undergoing advanced clinical trials.
Pituitary related Testosterone Deficiency
Various medications are being used to stimulate the Pituitary gland to work
HCG is used where the testosterone production signallers (LH and FSH) are not working.
HGH is used when growth hormone is shown to be absent.
Some Herbal preparations have been used to good effect.
Zinc has been shown to reduce Prolactin levels.
SHBG related testosterone Deficiency
Danazol has been used to reduce SHBG.
It is generally accepted that a daily application of Testosterone is the best method of supplements. Despite the virtues of slow-release mechanisms in the longer term supplements, there are inherent risks attached to their use.
Injections cause a "peak and trough" effect, which is only overcome by reducing the frequency of administration. When that happens, the peak tends to result in higher than normal levels, in a system that expects consistent levels when in its natural state.
Implanted pellets are extremely good at providing a steady flow of Testosterone into the body. However dose adjustments are clumsy and there is always a risk of pellets being ejected through the incision site.
Transdermal patches have been arounbd a long time, but manufacturers have yet to overcome patient complaints of noise, lack of adhesion and skin irritations.
Oral pills are quite simply not the best way to go. Although Andriol in capsule form is used widely in various parts of the world, its efficacy in relation to gels is in question.
Transdermal gels are the "new kids on the block". Research into it's properties suggest they do a much better job than any other form of supplements. Patients tend to agree, however, some patients don't like the gooey nature of it, others are concerned about the risk of transferrence to a partner or child.
Good treatment is not a matter of luck.
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Opinion
It is considered that careful use of Transdermal gels is the best method of supplement at this stage.
Dosing cannot yet be controlled well enough to ensure all patients attain their correct levels, thus providing the steady flow expected by the body, but We are aware of a new patent for a 1mg gel pack, which will increase the options available and allow fine tuning of doses to attain the required levels.
Although costs are higher than other options,market forces should reduce the price quickly, as new manufacturers are coming into the market.
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